Justicia secunda Vahl belonging to the family Acanthaceae is known as “Blood root” and “Sanguinaria” in Barbados and Venezuela respectively. The folkloric. Justicia secunda Vahl (Acanthaceae), a native tropical herbaceous plant originating from South America, is nowadays grown in other tropical or subtropical. Request PDF on ResearchGate | On Dec 14, , BA Theiler and others published Identification of Justicia secunda Vahl by IR spectroscopy.
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Justicia secunda | TRAMIL
Anthocyanins from Justicia secunda were found to possess anti-sickling activity. At each step of the pilot plant process, the co-products obtained were analyzed for total polyphenol and total flavonoid contents by the UV-vis spectrophotometric method. This lead to the changes in the shape of red blood cells and anaemia. Industrial Crops and Products Water extracts of Justicia secunda leaves are used by village communities in southern countries to prepare traditional medicines at home.
Sickle cell disease or drepanocytosis is caused by the polymerisation of abnormal haemoglobin S when oxygen tension decreases. Sefunda findings suggest that anthocyanin extracts play a role in both stabilising the red blood cell membrane and inhibiting polymerisation of haemoglobin S.
These ions are bound to membrane proteins resulting in dehydration and loss of red blood cell deformability and cell-to-cell adherence.
Site du Cirad Annuaire des sites du Cirad. Justicia secunda is a plant used in Congo by Jehovah’s Witnesses, well known for their refusal of blood transfusions, against anaemia.
Polyphenol extraction and characterization of Justicia secunda Vahl leaves for traditional medicinal uses. It has also been postulated that the red cells of patients with sickle cell disease contain a higher than normal concentration of calcium ions.
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Publications des agents du Cirad. This provides secundaa possible molecular basis for earlier reports on the anti-sickling properties of anthocyanins from some Congolese plants and their use in the management of sickle cell disease by Congolese traditional healers. Treated SS red blood cells recovered a normal, classical biconcave form with a radius of 3.
As the processing conditions were milder than for homemade preparations, the extract obtained was enriched in natural leaf flavonoids. The beverage is usually obtained by boiling the plant in water.
The process allowed a better leaf water-extraction of polyphenol compounds than the homemade extraction. On a pilot plant scale, water extracts were processed using an extraction-concentration procedure achieved in a three-step process, including vanl water extraction followed by cross-flow microfiltration of the crude extract and its concentration by reverse osmosis.
Emmel, Itano and osmotic fragility tests were used to test the effect of anthocyanin extracts from Justicia secunda leaves on haemoglobin S secudna and sickle cell membrane stability.
Anthocyanins extracted from some Congolese plants used in traditional medicine against sickle cell disease have recently been shown to have anti-sickling activity in vitro. The solubility of deoxyhaemoglobin S increased and the osmotic fragility of drepanocytes decreased upon treatment with anthocyanin extracts.